| Japanese |
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| Title | 99mTc標識ピロ燐酸による骨シンチグラフィの臨床的検討 |
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| Subtitle | 原著 |
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| Authors | 浜本研*, 藤田透*, 高坂唯子*, 山本逸雄**, 坂本力**, 森田陸司**, 森徹**, 鳥塚莞爾** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線部, **放射線科 |
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| Journal | 核医学 |
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| Volume | 11 |
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| Number | 6 |
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| Page | 637-645 |
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| Year/Month | 1974/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I 緒言」シンチグラフィーに用いられる核種のうちでほぼ理想的な物理的性質を有する99mTcは, これまでに多数の放射性医薬品の標識に用いられて, 主要臓器の多くが99mTc標識物質によるシンチグラフィーが可能になっている. 骨においても従来用いられてきた85Sr, 87Sr, 18Fに代って比較的廉価な, 入手しやすい99mTc標識ポリ燐酸の骨シンチグラフィーへの導入は, 画期的なことであったといえる. その後本物質の難点として品質管理が困難で, 比較的短期間で変性することが報告され, 1972年にPerezらによって比較的安定な物質として99mTcピロ燐酸が報告され, そのキット化により容易に標識されて種々の骨疾患における骨シンチグラフィーに用いられている. 本稿では99mTc標識用ピロ燐酸キットを用いて若干の基礎的検討および臨床的検討を行った成績を報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Bone Scintigraphy with 99m TC-labeled Pyrophosphate. |
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| Subtitle | Original |
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| Authors | Ken HAMAMOTO, Itsuo YAMAMOTO, Rikushi MORITA, Tsutomu SAKAMOTO, Toru MORI, Toru FUJITA, Tadako KOUSAKA, Kanji TORIZUKA |
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| Authors(kana) | |
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| Organization | The Central Clinical radioisotope Division and The Department of Radiology, Kyoto University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 11 |
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| Number | 6 |
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| Page | 637-645 |
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| Year/Month | 1974/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Scintigraphy of bone and joint with 99mTc-labeled pyrophosphate and scintillation camera or whole body scanner was performed for 97cases with primary bone tumors, metastatic bone tumors, and other diseases of bone and joint. In 13 cases with primary bone tumors, positive results were obtained with exception of 2 of 5 cases with fibrous cortical defect whose results were negative. Any abnormal finding was not demonstrated on the X-ray films in 5 of 18 cases with metastatic bone tumors whose scintigraphies were positive. In some cases under chemotherapy, hormone therapy or radiation therapy, metastatic bone lesions were not demonstrated on scintigrams. All 8 cases with multiple myeloma showed rather decreased accumulation of 99mTc-pyrophosphate. The labeling procedures of pyrophosphate with 99mTc were simple and this preparation could be considered stable by descending paper chromatography in 85% methanol and clinical studies. It was concluded that scintigraphy with this material was useful to demonstrate the metastatic lesions in the bone and to determine the site and extent of the tumors. |
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| Practice | Clinical medicine |
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| Keywords | |
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