Japanese
Title瀰漫性肝疾患における198Au-コロイドの肝脾外分布
Subtitle原著
Authors油野民雄*, 鈴木豊*, 久田欣一*, 松平正道**
Authors(kana)
Organization*金沢大学医学部核医学教室 (主任久田欣一教授), **金沢大学付属病院中央RI部
Journal核医学
Volume11
Number4
Page465-470
Year/Month1974/8
Article原著
Publisher日本核医学会
Abstract「I. はじめに」肝シンチグラムによる肝硬変症の診断法として, 著者の一人久田らにより提唱された肝右側萎縮左側腫大脾出現像並びに特異的肝右側腫大像の定性的評価法, かつ肝右幅径と左幅径の差3cm以下もしくは9cm以上という基準による簡便な定量的評価法をすでに発表した. しかしかかる診断基準に合致する肝硬変は約50%にすぎず, 今回全身線スキャン法による198Au-コロイドの肝脾外分布率を求め核医学的方法による肝硬変症の診断向上をめざした. さらに従来より門脈圧亢進時のコロイドの肝外分布所見が注目されてきたが, 198Au-コロイドの肝脾外分布率と門脈圧亢進症状の有無, 肝スキャン所見との関連について対比検討を試みた. 「II. 対象並びに方法」生検, 腹腔鏡, 剖検並びに臨床所見より診断確定した亜急性肝炎2例, 慢性肝炎9例 (活動型4例・非活動型5例), 肝硬変25例, バンチ症候群1例, 血液並びに網内系疾患6例, その他肝疾患7例, 正常2例を対象とした.
Practice臨床医学：一般
Keywords
English
TitleThe Extrahepatosplenic Distribution Ratio of 198Au-Colloid in Diffuse Hepatic Disease
SubtitleOriginal
AuthorsTamio ABURANO*, Yutaka SUZUKI*, Kinichi HISADA*, Masamichi MATSUDAIRA**
Authors(kana)
Organization*Department of Nuclear Medicine, School of Medicine, Kanazawa University, **Division of Central Radiological Service, Kanazawa University Hospital
JournalThe Japanese Journal of nuclear medicine
Volume11
Number4
Page465-470
Year/Month1974/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]Several years ago, Hisada et. al. reported a simple guantitative criterion of the cirrhosis on 198Au-colloid liver scan i. e. right side breadth (R) - left side breadth (L) <= 3cm or >= 9cm. They also proposed two liver scan patterns which might be pathognomonic for the liver cirrhosis, one was right side atrophy and relative left side hypertophy of the liver with moderate splenic visualization and the other was specific hypertrophy of the right side of the liver. Only about half of cirrhosis, however, could be detected with these criteria. Therefore, the ratio of the extrahepatosplenic distribution to systemic distribution of 198Au-colloid was calculated in 52 various liver diseases to improve the diagnosis of the cirrhosis in nuclear medicine. The linear scanning of the whole body with isosensitive rectilinear scanner was performed for this purpose. The ratio showing the value higher than 20% suggested the probability of cirrhosis, because most of other diffuse hepatic diseases showed the ratio less than 20%, Twenty-three of 25 cirrhosis cases (92%) could be detected with both the extrahepatosplenic distribution ratio and a simple quantitative evaluation criterion, in contrast with fourteen of 25 cases (56%) with a simple quantitative evaluation only. The extrahepatosplenic ratio was fairly correlated with the degree of liver functional impairement, e.g. BSP (45 min.), ICG (15 min.), serum albumine and total cholesterol values, and abnormal liver scan findings, e. g. splenic activity, bone marrow activity, and patchy distribution of liver and/or increased background activity. In relation to the clinical manifestations of portal hypertension, the extrahepatosplenic ratio showed much higher value in the presence of these manifestations, and in these cases, lung visualization was frequently found on 99mTc-sulfur colloid liver scan. From these results, the quantitative evaluation of systemic 198Au-colloiddistribution state is supposed to be one of the most valuable means to improve the diagnosis of the cirrhosis in nuclear medicine, and to predict the state of portal hypertention or portosystemic collateral circulation. Lung visualization on 99mTc-sulfur colloid liver scan is also supposed to be a specific finding in cirrhosis with portal hypertension, provided that the probability of 99mTc-sulfur colloid macroaggregates could be entirely denied.
PracticeClinical medicine
Keywords

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