| Japanese |
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| Title | 代謝性骨疾患における47Ca Kinetic Study |
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| Subtitle | 原著 |
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| Authors | 富田明夫*, 高槻健介*, 今川卓一郎*, 内川厚司*, 藤田徹* |
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| Organization | *名古屋大学医学部第一内科 |
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| Journal | 核医学 |
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| Volume | 11 |
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| Number | 2 |
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| Page | 87-95 |
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| Year/Month | 1974/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」近年, 生体内のカルシウム (Ca) 代謝および骨代謝を動的にかつ総合的に把握するため 47Caを投与して, そのspecific activityの時間的推移から評価しようとする47Ca kinetic studyが試みられてきた. 著者らは種々の代謝性骨疾患の骨, Ca代謝異常を知るため, 47Ca kinetic studyを実施し, 生体内のCa pool量を測定し, さらに骨へのCa利用すなわち骨形成率, Bone formation rate (BFR) および骨からのCa放出すなわち骨吸収率, Bone resorption rate (BRR) を算出し, これら疾患の骨およびCa代謝異常の発現機序につき検討してきたので報告する. さらに一部の代謝性骨疾患において, 薬剤による治療効果を判定するため, 治療前後で47Ca kinetic studyを実施し, Ca pool量, BFR, BRRについて, 比較測定し, 本検査が有用であるかどうかを検討した「II. 対象」年齢21歳より74歳までの種々の代謝性骨疾患17例を対象として選んだ. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Calcium Kinetic Studies in Metabolic Bone Diseases |
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| Subtitle | Original |
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| Authors | Akio TOMITA, Kensuke TAKATSUKI, Takuichiro IMAGAWA, Takashi UCHIKAWA, Toru FUJITA |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Nagoya University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 11 |
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| Number | 2 |
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| Page | 87-95 |
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| Year/Month | 1974/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Calcium, phosphorus and nitrogen balances and calcium kinetic studies for the purpose of the analysis of bone metabolism were performed in 17 metabolic bone diseases - 5 patients with postmenopausal osteoporosis, 6 patients with Cushing's syndrome, 3 patients with chronic renal failure, one with hyperthyroidism, one with secondary hyperparathyroidism, one with bone metastasis of thyroid carcinoma. Kinetic analyses were carried out according to the single compartment model and the miscible calcium pool (E), the calcium turnover rate (K), the bone formation rate (BFR) and the bone resorption rate (BRR) were calculated by the equations of Heaney and Whedon, and Aubert, Bronner and Richelle. The following results were obtained. The patients with postmenopausal osteoporsosis had a reduced E, a decreased K and BFR, and an increased BRR, Calcium and phosphorus balances were significantly negative. In patients With Cushing's syndrome, E, BFR were decreased and BRR were increased as well as ill patients with postmenopausal osteoporosis, In 3 patients with chronic renal failure, a patient without azotemia had a decreased BFR and BRR but BRR never exceeded BFR while two patients with azotemia had negative calcium balances. In a patient with hyperthyroidism a marked increase of E, BFR and BRR, and negative calcium balance were observed as well as in a patient with secondary hyperparathyroidism. A patient with bone metastasis of thyroid cancer had negative calcium balance caused by a decreased BFR. These parameters were helpful in elucidating the pathogenesis of various metabolic bone diseases and it is suggested that bone manifestations in these diseases were resulted partly from the prolonged negative calcium balance. In addition, three patients with postmenopausal osteoporosis were studied by balance and 47Ca kinetic studies in order to determine the effect of a drug, vitamin K2. This therapy caused a decrease in the degree of negative balance with a reduction of pains. |
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| Practice | Clinical medicine |
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