| Japanese |
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| Title | Thyopac-4キットによるThyroxineのConventional及びDual Competitive Binding Analysis並びにその診断的意義について |
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| Subtitle | 原著 |
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| Authors | 浜田哲1), 高坂唯子2), 森徹2), 竹田洋祐3), 池窪勝治3), 鳥塚莞爾3), 植手鉄男4) |
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| Authors(kana) | |
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| Organization | 1)京大放射性同位元素総合センター, 2)京大医学部付属病院中央放射線部, 3)放射線科, 4)大阪北野病院臨床検査部 |
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| Journal | 核医学 |
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| Volume | 11 |
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| Number | 1 |
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| Page | 15-21 |
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| Year/Month | 1974/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「緒言」血中の遊離型サイロキシン (以下FreeT4) は, 直接細胞内に移行してホルモン作用に関与するために, 一般に甲状腺機能の最も良い指標とされている. 最近トリヨードサイロニン (以下, T3) の代謝における役割が重視されるに至つているが, 一部の例を除き, その値はサイロキシン値 (以下T4) にほぼ平行し, また末梢細胞でT4からT3への変換が起こることから, Free T4の測定は依然重要な意義をもつと考えられる. しかるにFree T4の平衡透析あるいは限外ろ過による測定は煩雑であり, かつ長時間を要するところから, これに代わつて, T4値と血清T4結合グロブリン (以下TBG) の指標とからFree T4に平行するFree T4 Indexを算出することが広く行われ, 臨床上有用であることが認められている. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Dual competitive protein binding analysis by Thyopac-4 kit, and its evaluation in the assessment of thyroid function |
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| Subtitle | Original |
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| Authors | Satoshi HAMADA1), Tadako KOSAKA2), TORU Mori2), Yosuke TAKEDA3), Katsuji IKEKUBO3), Kanji TORIZUKA3), Tetsuo UETE4) |
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| Authors(kana) | |
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| Organization | 1)Radioisotope Research Center, Kyoto University, 2)Central Clinical RI Division, and 3)Department of Radiology, Kyoto University School of Medicine, and 4)Division of Clinical Biochemistry, Kitano Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 11 |
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| Number | 1 |
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| Page | 15-21 |
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| Year/Month | 1974/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Conventional and dual competitive binding analysis of thyroxine (the latter called tentatively Thyopac "ETR") were performed simultaneously using a single kit of Thyopac-4. Thyopac ETR (X) was correlated significantly (γ=+0.96) with Free Thyopac Index (Y), representing a regression equation of Y=71.67 x2-88.40 X +24.18. The values obtained were significantly (p, 0.005) increased and decreased, respectively, in hyper-and hypo-thyroidism, whilst they remained within the normal range in pregnancy and TBG deficiency. Further, abnormal T4 values obtained despite normal ETR values indicated abnormality in TBG level such as TBG deficiency, It was concluded that the present method determining ETR as well as T4 values was very useful for assessment of thyroid function, the values being irrespective of change in TBG. |
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| Practice | Clinical medicine |
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