| Japanese |
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| Title | 131I-BSP血中停滞率10分値の臨床的検討 - 20μCi使用による - |
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| Subtitle | 使用経験 |
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| Authors | 前田敏男, 上野恭一, 油野民雄, 久田欣一 |
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| Organization | 金沢大学医学部核医学教室 (主任 : 久田欣一教授) |
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| Journal | 核医学 |
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| Volume | 10 |
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| Number | 6 |
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| Page | 571-575 |
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| Year/Month | 1973/12 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」131I-BSPによる肝機能検査は種々報告されているが, 肝スキャンの目的も含めて100μCi以上使用したものが多い. 100μCi以下の投与量による報告もあるが, 今回著者らは20μCi静注10分後の血中停滞率を求めたので報告する. 著者らの目的は, 被曝線量の軽減とスクリーニングテストとしての実用価値を検討することであつた. さらに198Auコロイドや, 99mTc2S7コロイド等の綱内系核種による肝スキャンと, 131I-BSP血中停滞率との対比検討も行つた. 「対象」1973年2月から5月の間に, 当科外来に肝の検査に訪れた111人と, 16名の健康者を対象とし, その中で診断の決定した104人について成績をまとめた. 生検, 腹腔鏡, 手術並びに臨床成績より診断された急性肝炎1例, 慢性肝炎10例, 肝硬変症16例, 閉塞性黄疸2例, 肝腫瘍2例, 及び脂肪肝や薬物性肝障害等その他の肝疾患8例などの肝疾患と, 消化管の腫瘍を含む肝以外の疾患について検討した. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | 131I-BSP blood retention test - 10 min. after injection of 20μCi of 131I-BSP - |
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| Authors | Toshio MAEDA, Kyoichi UENO, Tamio ABURANO, Kinichi HISADA |
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| Organization | Department of Nuclear Medicine, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 10 |
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| Number | 6 |
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| Page | 571-575 |
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| Year/Month | 1973/12 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] 131I-BSP blood retention tests were performed in 127 subjects including 35 with proven normal, 39 with proven liver diseases, 30 with proven extrahepatic diseases, and 23 with diagnosis unproven, based on clinical signs, laboratory data, and/or liver scannings. We utilized 131I-BSP kits supplied by Dainabott R.I.laboratory, Ltd. The 131I-BSP blood retention ratio was measured at 10 min. after intravenous injection of 20μCi of 131I-BSP solution. The circulation blood volume was predicted by methods of Ogawa & Fujita's equation. The radioactivity of sample was counted during 5 minutes with well-type scintillation counter. 131I-BSP blood retention ratio was calculated according to following formula, where Sa is cpm of sample of 1 ml, St is cpm of 20μCi 131I-BSP, B is cpm of back grounds, and C ml is predicted circulating blood volume. (Sa-B)×C÷(St-B)×100=131I-BSP blood retention ratio (%). In this methods, the relative error ratio was within 5%. 131I-BSP blood retention ratios of healthy persons were 16.8 +- 5.4%, and those of hepatic diseases were more elevated values (for example, chronic hepatitis was 28.6 +- 9.6%, and liver cirrhosis was 47.7 +- 6.7%). The coefficient of correlation of 131I-BSP blood retention ratios and I. C. G. (values at 15 min.), BSP retention test (values at 45 min.), G. P. T. and G. O. T. were obtained 0.81, 0.67, 0.57 and 0.44 respectively, Our data strongly suggest that a dose of 20μCi of 131I-BSP is enough for screening liver function. The reduction of a dose obviously decreases the exposure dose of patients. |
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| Practice | Clinical medicine |
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