| Japanese |
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| Title | 131I標識人血清アルブミンによる循環血漿量測定法の変法 - mock-iodineによる較正法 - |
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| Subtitle | 原著 |
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| Authors | 本原征一郎*, 斎藤宗靖*, 鈴木雅紹** |
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| Organization | *京都大学第3内科, **兵庫県立尼崎病院研究検査部 |
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| Journal | 核医学 |
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| Volume | 10 |
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| Number | 6 |
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| Page | 565-569 |
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| Year/Month | 1973/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「緒言」循環血漿量及び血液量は, 血行動態解析に際しての重要なパラメータのひとつであり, その値を正確に, 繰り返し, しかも労なく測定できることが, 日常臨床に活用するための必要条件である. 現在実用に供されている測定原理は稀釈法であり, 稀釈物質としては, 血管外への漏出のない色素や放射性同位元素が利用されているが, 最近は131I標識人血清アルブミン(RISA)を用いる方法が一般的となつている. しかしながら, 従来のRISAによる循環血漿量測定法は測定の度に較正のための稀釈標準液を作る必要があり, きわめて繁雑であるとともに測定値のばらつきの原因にもなつていた. これらの欠点を改善するために, 我々は放射性沃素模倣線源(mock-iodine, 以下MIと略す)を稀釈標準液の代用として用いることにより, 簡単な操作で安定した循環血漿量を得る方法を考案したので報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Modified Method for the Determination of Circulating Plasma Volume by 131I-RISA - Calibration with Mock-Iodine - |
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| Subtitle | Original |
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| Authors | Seiichiro MOTOHARA*, Muneyasu SAITO*, Masatsugu SUZUKI** |
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| Organization | *The Third Medical Clinic, Kyoto University Hospital, **Kenritsu Amagasaki Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 10 |
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| Number | 6 |
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| Page | 565-569 |
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| Year/Month | 1973/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Circulating plasma volume (CPV) or blood volume is one of important circulatory parameters that reflect the cardiovascular abnormality. Various technics were reported for the determination, among which the dilution method with nondiffusible radioisotope (131I-RISA) have been presumed to be the best one. The purpose of this paper is to make the modification of the method, using mock-iodine capsules for the calibration. Two mock-iodine capsules are prepared: One has radioactivity of about 50μCi (large-dose MI), and the other less than 0.1μCi (small-dose MI). These activities roughly correspond with those of injected RISA and of 1 ml of plasma, respectively. Circulating plasma volume can be determined by the following equation: CPV=PS/PW×MW/MS×k×f(t) ×1000 (1) where PS; net activity of RISA injected to a patient. PW; activity of RISA in 1 ml of plasma. MS; activity of large-dose MI. MW; activity of small-dose MI. k; a constant determined by the equation (2). t; time elapsed since the measurement of PS to PW. f(t); decay rate of 131I in t hour. Determination of k is made from equation (2)by making several 1000 ml-standard solutions. k=SW/SS×MS/MW×1/f(t) (2) where SS; net activity of RISA used for the preparation of 1000 ml standard solution. Sw;activity of RISA in 1 ml of standard solution. t; time elapsed since the measurement of SS to SW. Once k is determined accurately, the same k value Can be used in equation (1), and there is no need to prepare standard solutions thereafter. The value of k determined from seven standard solutions in our laboratory was 0.5777 +- 0.0047 (mean +- SD). Seventeen solutions of RISA were prepared in three different sizes of flask (1000 ml, 2000 ml and 3000 ml), and their volumes were calculated from equation (1). Calculated volumes showed very close agreement with flask volumes, and mean +- standard deviation of calculated volume/flask volume was 0.998 +- 0.010. |
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| Practice | Clinical medicine |
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