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| Title | 67Ga-citrateによる肝シンチグラフィおよびコンピューターシンチグラムの肝臓癌診断への応用 |
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| Subtitle | 原著 |
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| Authors | 湯本泰弘, 田中義淳, 難波経雄, 小坂淳夫* |
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| Organization | *岡山大学医学部 第一内科 |
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| Journal | 核医学 |
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| Volume | 10 |
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| Number | 5 |
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| Page | 467-477 |
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| Year/Month | 1973/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「緒言」放射性コロイドによる肝スキャンニングは原発性肝癌および転移性肝癌の診断に広く応用されている. 198Au-colloid, 99mTc-sulfur colloidは主として肝臓のKupffer星細胞に摂取されることを利用して正常肝組織を描出するもので, 肝腫瘍は局所的に綱内系への取り込みの減少ないし, 欠損部分として描出される. 一方癌親和性RIの開発が長い間待望されたのであるが, ようやく1969年にEdward and Hayesによつて67Ga-citrateが悪性リンパ腫で著明に摂されることが報告された. それ以来, 種々な臓器の腫瘍についても67Ga-citrateが病巣を陽性像として描出することが次第に判明し, 1970年Wincleは67Ga-citrateが原発性肝癌によく取り込まれた1例を報告し, その後同様な報告がみられるに至つた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Study on Computer Scintigraphy for Detecting Liver Tumor by Scintillation Camera with 67Ga-citrate |
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| Subtitle | Original |
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| Authors | Yasuhiro YUMOTO, Yoshikiyo TANAKA, Tsuneo NANBA, Kiyowo KOSAKA |
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| Organization | The First Department of Internal Medicine, Okayama University Medical School Okayama |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 10 |
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| Number | 5 |
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| Page | 467-477 |
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| Year/Month | 1973/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The usefullness of scintiphotography, particularly computer scintigraphy, using 67Ga-citrate and the scintillation camera for detecting and differentiating the tumour of the liver was evaluated. Nineteen patients bearing focal defects on the livec scans with radiocolloid were studied with 67Ga-citrate. Images of the liver were obtained 48 to 72 hours after injection of 1 to 2 mCi of 67Ga-citrate intravenously. A scintillation camera (Pho/Gamma III) was used, and all images were recorded on Polaroid films. In addition to the conventional Polaroid photographs, the data were also feded into computer system and stored in the memory cores. Definite tumour accumulation of the 67Ga-citrate was noted in 14 of 15 patients with malignant tumors - 4 of 5 with hepatocellular carcinomas, 3 of 9 with metastatic liver tumours. The tracers were poorly accumulated by a hepatocellular carcinoma, a cholangiohepatic carcinoma, and five metastatic liver tumors. The gallium study were found to be helpful in the differential diagnosis of focal liver abnormalities detected by 99mTc-sulfur colloid scans. A focal liver abnormality that accumulated more gallium than surrounding normal tissue was more likely to be malignant tumor than benign condition such as cirrhosis. The combination of 67Ca-citrate and 99mTc-sulfur colloid was found to be helpful to distinguish the patients with hepatic malignancies to those with cirrhotic scarring. After the 67Ga study was perfermed with leaving the patient in the same position under the detector, we gave 1 mCi of 99mTc-sulfur colloid intravenosly and again obtain a san image of the liver. All data were stored in the tape recorder to provide it for computer scintigraphy and for subtraction scintigram. Gallium-67 citrate distributes also within the normal liver tissue. This made it difficult to deliniate the tumor image of the liver. The computer subtraction scintigraphy with the use of 67Ga-citrate and 198Au-colloid or 99mTc-sulfurcolloid allow to overcome the disadvantage of 67Ga-citrate. These results suggested that 67Ga-citrate scintigraphy or particularly computer scintigraphy, was clinically useful in diagnosing the presense and location of malignant tumors in the liver. |
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| Practice | Clinical medicine |
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