| Japanese |
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| Title | 新しいin vitro test - "Res - O - Mat ETR" Diagnostic Kit - による甲状腺機能検査法について |
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| Subtitle | 原著 |
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| Authors | 中川昌壮1), 井上純一1), 長島秀夫2) |
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| Organization | 1)熊本大学医学部第3内科教室, 2)主任:教授 |
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| Journal | 核医学 |
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| Volume | 9 |
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| Number | 6 |
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| Page | 551-560 |
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| Year/Month | 1972/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」1957年Hamolskyらにより, 患者赤血球への131I-triiodothyronine(131I-T3)の結合の度合が, その甲状腺機能によく相関するという現象の発見に端を発し, 患者血清をin vitroで131I-T3とincubateし, 結合蛋白と結合しないものをresin spongeに吸着させ, その率でもって表現される131I-T3 resin sponge uptake(131I-T3 RSU)が開発された. RIを人体内に投与することなく, 少量の被検血清を用いたin vitroでの簡便な操作で甲状腺機能に相関の高い指標が得られる検査法として非常に広く普及し, 日常診療上多くの利益をもたらして来た. さらに, competitive protein binding analysis(CPBA)の考え方を用いて, 血中thyroxineの微量定量化に成功してから, 直接的に甲状腺ホルモン濃度を測定することが出来, すぐれた甲状腺機能の表現と見なすことが出来るようになった. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | The Thyroid Function Test with the New in - vitro Diagnostic Kit - "Res - O - Mat ETR Test" - |
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| Authors | Shoso NAKAGAWA1), Junichi INOUE1), Hideo NAGASHIMA2) |
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| Organization | 1)The Third Department of Internal Medicine, Kumamoto University Medical School, 2)Chief: Prof |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 9 |
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| Number | 6 |
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| Page | 551-560 |
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| Year/Month | 1972/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Recently we have made the some basic and clinical studies on the evaluation of thyroid function with Res-O-Mat ETR diagnostic kit, which was newly developed as the thyroid function test dy Mallinckrodt Chemical Works. Results were summarized as follows: 1) The amount of patient and standard serum introduced into the reactive vials is 0.005-0.01 ml, which are shown by the investigation to be the proper volume for excellent discriminations between euthyroid-hyperthyroid and euthyroid-hypothyroid sera. 2) The test should be performed below 25℃. 3) The reproducibilities of ETR in the same and the different kits are fairly good. 4) The values of ETR for 12 normal control sera are 0.96+-0.04(mean+-one standard deviation). 5) The ETR in the sera of the euthyroid pregnant and TBG deficient patients are distributed within normal limit, while their T3 TBC Index and T4 concentrations are almost abnormal. 6) The correlation coefficients between ETR and T3 TBC Index, ETR and T4 concentration, ETR and Free T4 Index are respectively -0.56, +0.84 and +0.92. On the basis of these results, the authors can conclude that the Res-O-Mat ETR test is simple but more reliable than the other in-vitro thyroid function tests, because the single test procedure can provide us with an indication of"free"or"effective"thyroxine which is proved to be |
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| Practice | Clinical medicine |
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