| Japanese |
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| Title | Res-O-Mat ETR Testによる甲状腺機能の診断 第一報 Effective Thyroxine Ratio (ETR) の臨床的評価 |
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| Subtitle | 原著 |
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| Authors | 稲田満夫, 岡部純一, 風間善雄, 高山英世, 春名桃江, 高橋浩 |
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| Organization | 天理よろず相談所病院 内分泌内科 臨床病理部 |
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| Journal | 核医学 |
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| Volume | 9 |
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| Number | 5 |
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| Page | 475-481 |
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| Year/Month | 1972/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」血中遊離型thyroxine(以下Free T4とする)濃度は最も重要な甲状腺機能の指標である. 近年, 血中T4濃度と131I-T3 resin摂取率の積がFree T4濃度と極めて良く平行することが知られ, このFree T4 Indexが甲状腺機能の診断に広く用いられている. Free T4濃度は血中T4結合α-globulin(TBG)のT4結合能および血中T4濃度に密接に関連する. 最近, 米国Mallinckrodt社よりこの両者を組合わせ, Free T4濃度の指標としてEffective Thyroxine Ratio(ETR)を測定するKitが発売された. 本稿において, その使用経験を述べ, 甲状腺機能の診断に, ETR kitの有用性について検討したい. 「検査対象」検査対象は健康人9例, Euthyroid"Sick"として肝または腎疾患患者5例, 治療前および治療後の甲状腺機能亢進症患者31例, 未治療甲状腺機能低下症患者14例, 非中毒性甲状腺腫患者6例, 妊婦10例, さらにidiopathicTBG増加症およびTBG減少症各1例, 計77例である. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Diagnosis of thyroid function by Res-O-Mat ETR Test I. Clinical evaluation of Effective Thyroxine Ratio (ETR) |
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| Authors | Mitsuo INADA, Junichi OKABE, Yoshio KAZAMA, Hideo TAKAYAMA, Momoe HARUNA, Hiroshi TAKAHASHI |
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| Organization | Endocrine Section, Department of Internal Medicine and Department of Clinical Pathology, Tenri Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 9 |
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| Number | 5 |
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| Page | 475-481 |
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| Year/Month | 1972/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] (1) A new thyroid test, referred to as the Res-O-Mat ETR Test has been developed by Mallinckrodt/Nuclear. This is a single direct, in vitro thyroid function test which can simultaneously consider both the total serum thyroxine concentration and the binding capacity of TBG, thus indicating the metabolically "effective" thyroxine level in serum(Effective Thyroxine Ratio). (2) In the present study, determinations were made of effective thyroxine ratio (ETR) in 9 cases of normal subjects, 5 cases of euthyroid "sick" patients, 31 cases untreated and treated thyrotoxicosis, 14 cases of untreated hypothyroidism, 6 cases of nontoxic goiter, 10 cases of pregnancy, and 2 cases of patients with abnormal TBG capacities. (3) The ETR values in normal subjects ranged from 0.95 to 1.06 (Mean+-SD=0.99+-0.04). No significant difference was found between the ETR values in normal subjects and those in euthyroid "sick". Moreover, the ETR values in pregnancy and in patients with abnormal TBG capacities were within normal range. (4) Patients with untreated thyrotoxicosis had elevated ETR values (Mean+-SD=1.32+-0.10), where as ETR values in those with hypothyroidism were diminished (Mean+-SD=0.81+-0.04). There were no overlappings between ETR values in thyrotoxicosis or in hypothyroidism and those in normal subjects. (5) Striking correlation was evident in the plots of ETR values against serum free thyroxine concentrations determined by magnesium precipitation method (r=+0.93). Thus, the ETR value provided a precise measure of thyroid status irrespective of serum binding protein abnormality. |
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| Practice | Clinical medicine |
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