| Japanese |
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| Title | Xe-133クリアランス法による前脛骨筋血流量測定成績とその臨床的評価 |
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| Subtitle | 原著 |
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| Authors | 厚美利行, 本田由美子, 松田政勝, 礒兼則子, 柳沢通子, 島本多喜雄 |
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| Organization | 東京医科歯科大学 第3内科 |
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| Journal | 核医学 |
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| Volume | 9 |
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| Number | 3 |
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| Page | 273-280 |
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| Year/Month | 1972/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 四肢の血流を測定する方法としては古典的にはocclusion pletysmgraphyによる方法があり, また最近はmercury strain gage plethysmographyによる方法またはDopplerの原理を用いて超音波による方法などがあるが, 前二者は操作が繁雑である難点があり, 後者は血流量の絶対値が算出出来ないという難点がある. 最近LassenらによりXenon-133を筋肉内に注射することにより注射局所の筋肉血流量を測定することが可能となり, 操作も簡便で患者に与える侵襲も少なく, 筋肉血流量が定量的に測定出来るようになった. 著者らはこの方法を用いて閉塞性動脈硬化症患者の下肢筋血流量を測定し, Pyridinolcarbmate治療により筋血流量が増加するという知見が得られたので報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | The measurement of blood flow through anterior tibial muscle by Xe-133 clearans method and it's clinical evaluation |
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| Authors | Toshiyuki ATSUMI, Yumiko HONDA, Masakatsu MATSUDA, Noriko ISOKANE, Michiko YANAGIZAWA, Takio SHIMAMOTO |
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| Organization | Tokyo Ika-Shika National University Fuculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 9 |
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| Number | 3 |
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| Page | 273-280 |
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| Year/Month | 1972/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The blood flow of anterior tibial muscle was measuredin 129 legs (65 individuals) by Xenon-133 clearance method. Musce blood flow was 1.57+-0.18 cc/100g/minute in healthy 32 limbs, 1.77+-0.26 cc/100g/minute in unaffected 19 limbs of atherosclerosis obliterans and 1.50+-0.13 cc/100g/minute in affected 68 limbs without cyanout cyanosis and ulcer. There were no statistically significant changes among these thsee groups. However, muscle blood flow was 1.0+-0.16 cc/100g/minute in 11 limbs with cyanosis and ulcer (p<0.01). Blood flow was significantly augmented in the limbs treated with pyrididinolcarbamate compared with non-treated limbs (p<0.01). Post-ischemic reactive blood flow was measured by the same method directly after releasing cuff which was covered the proxymal part of the leg. Results obtained by this metod revealed that muscle blood flow increased more markedly in the non-affected limds than in the affected ones and the affected limbs was succeeded in separating from the non-affected limbs. Furthermore, differences in the repeat measurement were so small that this modified method was thought to be more useful in evaln ating the extent of ischemic condition and effectiveness of drug treatment. Reactive blood flow through anterior tibial muscle was less than 10 cc/100g/minute intne non-treatreated 6 limbs. However, it was more than 10 cc/100g/minute in 14 out of 31 legs treated with pyrdinolcarbamate for long time. And one case was demonstrated whose reactive muscle blood flow was augmented from 2.0 cc/100g/minute before treatment to 10.3 cc/100g/minute after 22 weekeeks of treatment, |
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| Practice | Clinical medicine |
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