| Japanese |
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| Title | 203Hg-Salyrganによる腎シンチグラム - 特にBALおよびD-Penicillamineによる放射性水銀の排泄促進効果について - |
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| Subtitle | 原著 |
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| Authors | 伊東重光*, 矢崎雄彦*, 三島厚**, 田宮正**, 近藤智昭** |
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| Organization | *名古屋大学小児科, **名古屋大学放射線部RI検査室 |
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| Journal | 核医学 |
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| Volume | 9 |
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| Number | 1 |
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| Page | 31-38 |
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| Year/Month | 1972/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 腎シンチグラムは腎の位置, 形態, 機能を容易に知りうるので, 極めて有意義な検査法の一つであり, 特殊な装置を必要とするものの比較的重症な患者にも適用しうるので, その価値は大きいといえる. 本邦では主として経済的事情から, ほとんど203Hg-Chlormerodrin(Neohydrin)が用いられているが, 腎からの排泄が遅いため被曝線量が比較的多く, 小児に用いるのは不適当である. 203Hg-Salyrganはzum Winkel以来, ドイツを中心に広く用いられ, 優れた薬剤であることは数多くの報告にみる通りで, 小児にも適するとされているが, 本邦では近年まで市販されていなかったために利用されていない. われわれは最近これを試用する機会を得たので各種腎疾患に使用し, 203Hg-Chlormerodrinとくらべて排泄がはるかに早く, 従来の報告通り優れた薬剤であることが確認できた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | The Effect of Dimercaprol (BAL) and D-Penicillamine on the Total-Body Clearance of 203Hg-Salyrgan |
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| Authors | S.ITO*, T.YAZAKI*, A.MISHIMA**, T.TAMIYA**, T.KONDO** |
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| Authors(kana) | |
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| Organization | *Dept. Pediatrics, Nagoya University School of Medicine, **Radioisotope Laboratory, Nagoya University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 9 |
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| Number | 1 |
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| Page | 31-38 |
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| Year/Month | 1972/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We investigated the effect of some chelating agents on the total-body clearance of 203Hg-Salyrgan. Renal scintiphoto was taken in 38 children suffering from renal diseases. Several renal function tests were performed in all these children, and proved to be normal in 27 cases and abnormal in 11 cases. The cases with normal function were divided into three groups as follows: (1) Radiosalyrgan was administered without chelating agent (10 cases). (2) Radiosalyrgan was administered with 3 mg/kg of BAL (i.m.) two or three times (10 cases). (3) Radiosalyrgan was administered with 600-1,200 mg/day of D-Penicillamine (per os) for three days (7 cases). They were followed up to 4 weeks and measured the total-body retention. In the first control group 24-hr. 1-week and 4-week total-body retention was 18.6+-8.6%, 9.9+-4.6% and 3.8+-1.7%, respectively. These results are about a half of the retention of 203Hg-Chlormerodrin. In the second BAL administered group, it was 12.8+-5.4%, 6.0+-3.1% and 4.2+-0.7%, respectively. In the third D-Penicillamine admnistered group, the retention was 12.4+-3.2%, 2.8+-0.8% and 2.0+-0.7%, respectively. Though there were no statistical differences in our small series, we can find a tendency to decrease the retention with such chelating agents. Further investigation will be expected. |
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| Practice | Clinical medicine |
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