| Japanese |
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| Title | 二重標識法を用いた腎機能検査, 特に二重標識測定上の問題点について |
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| Subtitle | 原著 |
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| Authors | 櫻井勗*, 木村和文**, 久住佳三***, 猪熊正克****, 細見孝吉**** |
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| Organization | *大阪大学 泌尿器科学教室, **第1内科学教室, ***放射線科, ****RI実験室 |
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| Journal | 核医学 |
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| Volume | 9 |
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| Number | 1 |
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| Page | 13-22 |
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| Year/Month | 1972/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | RIの1回静注・体外計測法による腎クリアランスの測定法は操作が簡単で, 採尿を必要としない, 敏速に結果の得られる長所があり, 尿路通過障害のある場合特にその長所が生かされる有用な検査法である. Hippuran(HIP)を用いればRPFの近似値を, Iothalamate(IO)を用いればGFRを測定できるので, 同時記録したレノグラムの情報と合せれば尿排泄動態を含めた腎機能の定量的把握が可能である. 今回は二重標識法を応用して 1)HIPとIOを用いたRPFとGFRの同時測定, 2)HIP-とIO-レノグラムの同時記録, 3)更に203Hg-または197Hg-chlormerodrin(CHL)摂取曲線とHIP-またはIO-レノグラムの同時記録を試みるとともに, 二重標識法による測定上の問題点を検討したので報告する. 「方法」島津製UTC-12レノグラム装置を用いた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Evaluation of A Double Isotope Technique In Renal Function Studies |
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| Authors | Tsutomu SAKURAI*, Kazufumi KIMURA**, Keizo KUSUMI***, Masakatsu INOKUMA****, Takayoshi HOSOMI**** |
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| Authors(kana) | |
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| Organization | *Departments of Urology, **The First Department of Internal Medicine, ***Radiology, ****RI Laboratory, Osaka Univ, Hospital, Osaka Univ. Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 9 |
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| Number | 1 |
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| Page | 13-22 |
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| Year/Month | 1972/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] With a double isotope technique, simultaneous determination of glomerular filtration rate and effective plasma flow, combined with simultaneous renography of hippuran and iothalamate are carried out. Simultaneous tracing of 197Hg-chlormerodrin uptake curve is also investigated. Renal clearances of 131I-or 125I-hippuran and 125I-or 131I-iothalamate were measured by a single injection, external counting method using a two compartment analysis. The specimens from blood and urine were counted in a Shimadzu well-type scintillation counter with window setting for 131I and 125I respectively. Around 12 per cent of the counts at the131I setting were included in the counts at the 125I-setting of the counter, and were subtracted from the counts at the 125I setting to give the net 125I counts. In tracing of renographic and disappearance curves, the rate of 131I counts in the 125I window was proved to be changed by many factors, such as physiological difference in the kidney position, and difference in the kinetics of radioisotope carriers. At present a subtraction formula could not be obtained to correct the error accurately. However, when 125I was used with over three times larger dose than 131I, and hippuran was selected to the 131I-carrier, and iothalamate to the 131I-carrier, the error might be negligible. In simultaneous trcing of chlomerodrin uptake curve with renography, it was found that the effect of 131I on 197Hg counting could be negligible when 197Hg was used with over ten times larger than 131I, and that 203Hg could not be matched with 125I because of inevitable high radiation dose. |
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| Practice | Clinical medicine |
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