| Japanese |
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| Title | Tetrasorb-125I-Kitによる血中Thyroxine量の測定 特に甲状腺機能亢進症の治療効果の判定におけるTetrasorb値の有用性並びにT7値の臨床的意義について |
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| Subtitle | 原著 |
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| Authors | 稲田満夫, 葛谷英嗣, 岡部純一, 風間善雄, 高山英世 |
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| Organization | 天理よろづ相談所病院 内分泌内科 |
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| Journal | 核医学 |
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| Volume | 8 |
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| Number | 6 |
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| Page | 451-461 |
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| Year/Month | 1971/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」血中Thyroxine(以下T4とする.)量は甲状腺機能の重要な指標であり, その測定によって甲状腺疾患の診断はより確実になった. 近年, 血中ホルモン濃度の測定にCompetitive Protein Binding Assayが導入され, 血中T4量も本法を原理としたTetrasorb-125I-kitにより測定されるに至った. この血中T4量測定法は操作が簡単で, 現在広く日常検査として用いられ, その基礎的および臨床的検討に関して数多くの報告がみられる. しかしながら, その多くは甲状腺疾患の治療前の成績であり, 治療後の血中T4量の変動およびその臨床的意義に関する報告に乏しい. 著者らは対象群および各種甲状腺疾患患者の131I-Triiodothyronine Resin Sponge Uptake(Triosorb)およびTetrasorb-125I-kitにより血中T4量(以下Tetrasorb値とする.)を測定し, 特にTetrasorb値が甲状腺機能亢進症の治療効果の判定に, またその再発の早期発見に非常に有力な指標である事を認めた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Clinical studies on determinations of thyroxine concentrations in sera by Tetrasorb-125I-Kit. |
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| Authors | Mitsuo INADA, Junichi OKABE, Yoshio KAZAMA, Hideo TAKAYAMA |
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| Authors(kana) | |
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| Organization | Endocrine Section, Department of Internal Medicine, Tenri Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 8 |
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| Number | 6 |
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| Page | 451-461 |
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| Year/Month | 1971/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] (1) In 140 cases of hospital controls, 79 cases of untreated thyrotoxicosis, 217 cases of treated thyrotoxicosis, and 69 cases of untreated hypothyroidism, determinations were made of 131I-triiodothyronine resin sponge uptake (Triosorb) and of thyroxine in serum by competitive protein binding (Tetrasorb). In addition, free thyroxine indices (T7 values) were obtained by the products of Triosorb and Tetrasorb values. (2) In patients with untreated thyrotoxicosis, both Triosorb and Tetrasorb values were markedly elevated, and thyrotoxic patients, who were in euthyroid state after treatment, had almost normal Triosorb and Tetrasorb values. In group of thyrotoxic patients, who were still in hyperthyroid state after treatment, 23 of 83 cases had almost normal Triosorb values, while all but one case had elevated Tetrasorb values. The results indicate Tetrasorb was the useful indicator of thyroid function in thyrotoxic patients after treatment. (3) Patients with untreated thyrotoxicosis had elevated T7 values (11.81+-3.52vs. 2.87+0.69 in the contols), whereas T7 values in those with hypothyroidism were diminished (0.67+-0.30 vs. 2.87+-0.69 in the controls). The values of Triosorb and of Tetrasorb in untreated thyrotoxicosis and hypothyroidism differed less from control group than T7 values, accordings to analysis of variavce (p <0.01). Striking correlation was evident in the plots of T7 values against free thyroxine values in sera (magnesium precipitation method). Thus, T7 values were most useful indicators of thyroid function. |
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| Practice | Clinical medicine |
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