Japanese
Title131I-BSPによる肝機能検査
Subtitle原著
Authors鳥塚莞爾*, 浜本研*, 森田陸司*, 藤井正博*, 向井孝夫*, 高坂唯子*, 伊藤憲一**, 中川潤**, 水口千里**
Authors(kana)
Organization*京大 中央放射線部, **京大 第2内科
Journal核医学
Volume8
Number3
Page143-154
Year/Month1971/6
Article原著
Publisher日本核医学会
Abstract「はじめに」1925年, RosenthalらによりBSP排泄試験が鋭敏な肝機能検査として報告され, 現在広く臨床検査に用いられているが, 1961年, TubisらによりBSPの131Iによる標識が行なわれ, 更に1968年, ダイナボットRI研究所により, この131I-BSPのmono体とdi体の分離合成が成功し, 131I-BSPのmono体の臨床利用の検討が行なわれ, すでに飯尾らにより詳細な報告が行なわれている.
Practice臨床医学：一般
Keywords
English
TitleLiver Function Test with 131I-BSP and Scinticamera
Subtitle
AuthorsKanji TORIZUKA*, Ken HAMAMOTO*, Rikushi MORITA*, Masahiro FUJII*, Takao MUKAI*, Tadako KOUSAKA*, Kenichi ITOH**, Jun NAKAGAWA**, Chisato MINAGUCHI**
Authors(kana)
Organization*The Central Clinical Radioisotope Division, and **the Second Division of Internal Medicine, Kyoto University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume8
Number3
Page143-154
Year/Month1971/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] The present report deals with the usefulness of 131I-BSP (Dainabot Radioisotope Laboratory) for the liver function test with scinticamera (Pho/Gamma III) , 1600 channel analyzer and computer compatible magnetic tape system. One hundred and fifty μCi of 131I-BSP was injected intravenously to normal subjects and patients with various liver and gallbladder diseases, and the camera was activated with the detector head over the liver. Exposures were made at three minute intervals for a period of one and a half hours, and the distribution of radioactivity in the liver was accumulated by the 1600 channel analyzer, and was transferred to the magnetic tape, successively. On the serial scintiphotos, liver deformity, change of 131I-BSP distribution in the liver, space occupying lesion in the liver and appearance of 131I-BSP in the gallbladder and intestine were visualized. From the chronological change of radioactivity in the entire liver fed into the magneic tape, the time lapse before maximum liver uptake of 131I-BSP was determined with the digital computer (FACOM 230-60) . These occurred at 12-20 minutes in normal subjects, 20-30 minutes in chronic hepatitis, over 30 minutes in liver cirrhosis, 20-33 minutes in liver tumor and cholelithiasis, and over 90 minutes in extrahepatic obstructive jaundice, and these reflected liver function well. In this study, another scintillation detector was placed on the head of the patient, and the rate of decline in blood radioactivity was monitored over the whole period, and the percent retention of 131I-BSP in serum was compared. The blood was drawn at 30 minutes and 90 minutes after the administration of 131I-BSP, and the 131I-BSP concentration in serum at 30 minutes was obtained. After drawing the blood at 90 minutes, 20μCi of 131I-RISA and BSP solution (5 mg per Kg of body weight) were injected intravenously, and the blood was drawn at 10 minutes and 30 minutes. From the total serum volume obtained from the radioactivity of 131I-RISA in serum at 10 minutes and the 131I BSP concentration at 30 minutes, the percent retention of 131I-BSP at 30 minutes was calculated. The percent retention of BSP in serum at 30 minutes was determined from the blood at 30 minutes after the administration of BSP solution. From the percent retention of 131I-BSP in serum at 30 minutes and the blood 131I-BSP concentration curve monitored on tho head, the percent retention of 131I-BSP in serum at 20 minutes and 10 minutes were calculated, and the percent retentions at 10, 20 and 30 minutes were compared among normal subjects and various liver and gallbladder diseases. Percent retention of 131I-BSP in serum at 10 minutes was within 10% in normal subjects, 10-20% in chronic hepatitis, over 20% in liver cirrhosis, 10-20% in liver tumor, 65-80% in extrahepatic obstructive jaundice, and 8-18% in cholelithiasis, and a good correlation between the percent retention of 131I-BSP in serum at 10 minutes and percent retention of BSP in serum at 30 minutes was observed. Total serum volume was estimated from the body weight (W) and body height (H) according to Fujita's formula, as follows : male : (0.1682 H3+0.05049 W+0.4444)x0.62 female : (0.2502 H3+0.06253 W-0.6620)x0.62 The estimated percent retentions of 131I-BSP in serum at 10 minutes were obtained from the estimated total serum volume and 131I-BSP concentration in serum at 10 minutes in all the patients, and these were also extremely well correlated with measured percent retentions. From the above-mentioned results, the following procedures can be recommended as the routine test of 131I-BSP for obtaining the liver function and liver visualization. That is, the blood is drawn at 10 minutes after the intravenous administration of 131I-BSP, and the percent retention of 131I-BSP in serum at 10 minutes is estimated from the 131I-BSP concentration in serum at 10 minutes and the total serum volume from the body weight and height, and one time scintigraphy is performed at 30-60 minutes.
PracticeClinical medicine
Keywords

【全文PDF】