| Japanese |
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| Title | 131I-BSP継時的肝スキャニング法による体質性過ビリルビン血症の診断とその病態の検討 |
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| Subtitle | 原著 |
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| Authors | 飯尾正宏*, 山田英夫*, 千葉一夫*, 亀田治男*, 上田英雄*, 井内正彦**, 石和衛** |
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| Organization | *東京大学第2内科, **甲府市立病院内科 |
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| Journal | 核医学 |
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| Volume | 7 |
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| Number | 3 |
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| Page | 189-200 |
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| Year/Month | 1970/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」著者らはさきに131Iローズベンガルによる継時的肝スキャニング法 (1968山田, Taplin) について検討し, 現在なおもっとも広汎に使用されている肝代謝性色素であるBSPを131Iで標識して継時的肝スキャニング法に応用するため, その基礎的検討を行ないひきつづきその臨床応用ことに外科的, 内科的黄疸の鑑別診断法について報告した. 本研究の目的は, この131I-BSP継時的スキャニング法が, 「肝の摂取」「肝内運搬」および「肝外排泄」機序を容易且明瞭に可視化しうる利点に着目し, その機序と分類について現在なお論議の多い体質性過ビリルビン血症の診断と, 病態解析を行なうものである. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Studies on the Contiutional Hyperbilirubinemia using 131I-BSP Sequential Scanning Method |
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| Authors | Masahiro Iio*, Hideo Yamada*, Kazuo Chiba*, Haruo Kameda*, Hideo Ueda*, Masahiko Iuchi**, Mamoru Ishiwa** |
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| Authors(kana) | |
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| Organization | *Univ, of Tokyo, **Kofu City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 7 |
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| Number | 3 |
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| Page | 189-200 |
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| Year/Month | 1970/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | In order to establish another useful criteria for the difficult diagnosis of constitutional hyper-bilirubinemia 131I-BSP sequential scanning method was introduced. 131I-BSP (mono-iodide) With specific activities of 0.244mCi/mg was prepared as stable label by Dainabot Radioisotope Lab. Biochemical behaviour, application on the differential diagnosis of medical from surgical jaundices and simplified retention test of the 131I-BSP were studied. Advantage of this well evalnated dye for the present purpose is to make it possible to visualize clearly the mechanisme of "sinusoidal transport" and "canalicular excetion" of the liver. Among our experienced 33 cases of constitutional hyperbilirubinemia, 14 cases of Dubin-Johnson type, 8 cases of Rotor-type and 11 cases of Gilbert-type, 2 cases of Dubin-Johnson syndrome, 45 yrs male & 34 yrs. male, one case with Rotor-type, 59 yrs. male and one case of Gilbert-type. 31 yrs. male were evaluated by 131I-BSP sequential scanning produre. These cases were further investigated by other dyes such as BSP, ICG, 35S-BSP and 131I-Rose Bengal. Cases with Dubin-Johnson type were chracterized by the rapid uptake and clear visualization of the liver by 131I-BSP. However unlike normal who showed almost complete excretion of the dye into intestine within several hours, 131I-BSP stayed in the liver more than 20 hours with markedly retarded excretion into the intestine. Rotor-type was characterized by the delayed hepatic uptake of the 131I-BSP as well as all dyes studied, then, followed by the relatively un-impaired canalicular excretion of the dye. Gilbert type showed almost normal 131I-BSP uptake and excretion. Based on these findings it became possible to differentiate the complicated two types of conjugated hyper-bilirubinemias by sequential scanning procedure. Also these results lead us to the conclusion that these two types of conjugated hyper-bilirubinemia are no more closely related form as was postulated befor. Pathophysiological mechanism behind the Dubin-Johnson syndrome and Rotor type hyper bilirubinemia could be expressed as "excretory disturbance" and "sinusoidal transport disturbance" of 131I-BSP respectively. unlike 131I-BSP, 131I-RB failed to differentiate Dubin-Johnson and Rotor types by sequential scanning Procedure. |
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| Practice | Clinical medicine |
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