Japanese
Title131I標識ローズベンガルによる腹部スキャニング - 腎臓及び脾臓の描出について
Subtitle原著
Authors今枝孟義, 仙田宏平, 西岡清春
Authors(kana)
Organization岐阜大学放射線医学教室
Journal核医学
Volume7
Number2
Page94-104
Year/Month1970/6
Article原著
Publisher日本核医学会
Abstract「I. はじめに」ローズベンガルはFluorescin系のアルカリ性赤色色素であり, 1923年G. D. Delprat等により「選択的に肝臓に摂取され, 胆汁と共に排泄される性質のものである」ことが示された. 1955年Taplin等が131Iで標識したローズベンガルを用いて肝機能検査を施行して以来, RI検査の1つとして一般に広く用いられるようになった. 今回, 著者らは131I標識ローズベンガル(以下131IRBと略す)を使用して腹部スキャニングを施行した症例のうち, 肝機能障害の著しい症例において, 比較的多量のradioactivityを腎臓に認める一方, 脾臓および甲状腺にも認めたので, その量を検討すると共に, 臨床的意義について報告する. 「II. 検査方法」東芝製RDS6型スキャナー(3×2 inch Nal crystal, 37holes-15cm focusing collimator)を用い, 131IRBの注入量150〜300μCiをキュリーメーターで正確に測定し, 静注後直ちに患者を背臥位にさせ, 肝臓を含めた腹部スキャニングを施行した. 所要時間は20〜30分である.
Practice臨床医学：一般
Keywords
English
TitleRenal and Splenic Visualization on 131I Rose Bengal Abdominal Scans
Subtitle
AuthorsTakeyoshi Imaeda, Kouhei Senda, Kiyoharu Nishioka
Authors(kana)
OrganizationDepartment of Radiology. School of Medicine. Gifu University
JournalThe Japanese Journal of nuclear medicine
Volume7
Number2
Page94-104
Year/Month1970/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] The renal visualization on the radioiodinated rose bengal abdominal scans was recently pointed out by Eyler, Freeman et al., and we also confirmed this fact in eleven cases. Additionally we recognized splenic visualization in seven cases of eleven cases with renal appearance and in one case with no renal appaarence. Jacobson and others suggested that free- 131I could be main component of the radioactivity in the urine of patients with renal visualization, but we cannot agree to this suggestion of Jacobson and others. The renal visulization was recognized on 10 min. abdominal scan after intravenous injection of 131I-RB and the gastric appearance was shown clearly instead of kidney on abdominal scans after intravenous injection of 131I Na solution in the case with the renal visualizaton. Otherwise, paper chromatographic analysis of 131I-RB of Daiichi RI Laboratory showed mainly three Rf points of respectively near the origin, 0.45〜0.55 and 0.8〜0.9 of which the second point was identified 131I-RB itself with the amount of 96% of the total and the third point identified free- 131I with the amout of 3.7%. And then, the analysis of concentrated urine of the renal visualization showed mainly three Rf points of respectively near the origin, 0.1〜0.6 and 0.8〜0.9 of which the third point was identified the free- 131I with the amount of only 4.1% though we think to be necessary of still more investigation in the analysis to consider the influence of uric acid of concentrated urine. Accordingly we suppose that the main component of the radioactivity in urine may be 131I-RB itself (or its resemble subject). On the other hand, we recognized splenic visualization on immediate scan after intravenous injection of 131IRB in eight cases of which three cases showed the splenic images for over 24 hours. Mechanism of the visualization of kidney and spleen cannot be explained to be only the blood pool, since the dots of the intracardiac space on the scan was disappeared in 24 hours at longest after the injection. In case of the high degree of jaundice, bile pigment deposits in the space of the distal renal tubules in the form of colum, occasionally is also found in the cells of the renal tubules, and otherwise seems to be taken by RES in the spleen, Then, we assume that 131I-RB take the same attitude with bile pigment in vivo. On 131I-BSP abdominal scans, renal and splenic visualization were also recognized, but renal visualization was not clearly as compared with 131I-RB abdominal scans, We intend to study still more this problem by means of the microautoradiography on the like.
PracticeClinical medicine
Keywords

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