| Japanese |
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| Title | 131I-BSPの基礎的検討と臨床応用 |
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| Subtitle | 原著 |
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| Authors | 飯尾正宏, 右田徹, 井出和子, 亀田治男, 上田英雄 |
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| Organization | 東大上田内科 |
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| Journal | 核医学 |
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| Volume | 6 |
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| Number | 2 |
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| Page | 185-191 |
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| Year/Month | 1969/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 序言」1925年Rosenthal and Whiteらにより導入されたBSP色素は, 排泄試験として鋭敏な肝機能検査法であることが報告され, 今日なお非黄疸性肝疾患(肝硬変症, 初期肝炎, 肝腫瘍など)の最も鋭敏な検査法の1つと数えられている. BSPはその代謝過程で肝細胞による摂取, 貯蔵, グルタチオンとの抱合, 胆汁中への排泄という一連の過程を経るため, 排泄障害はこの4過程のいずれかの障害であり, 且つビリルビン代謝はBSPと競合するため, 黄疸疾患の鑑別診断には不適当とされてきた. すなわち一般に黄疸の存在する場合にはBSP試験は無意味であるか, やるべきでないともいわれてきた. 1955年Taplinらは同様な肝代謝性の色素rose bengalを131Iで標識し, この色素の排泄を肝上部で計測することにより, また後にBlahdらはこの方法で末梢プールを計測することにより, 比色計測を行なうことなく, 慢性, 亜急性肝疾患の診断に131Iローズベンガルを用いてきた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Fundamental Evaluation of 131I BSP and Its Clinical Application |
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| Subtitle | |
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| Authors | Masahiro Iio, Tohru Migita, Kazuko Ide, Haruo Kameda, Hideo Ueda |
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| Organization | 2nd Dept. of Medicine University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 6 |
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| Number | 2 |
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| Page | 185-191 |
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| Year/Month | 1969/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 1968 Yamada & Taplin introduced the method to differentiate the so-called medical and surgical jaundice by long term scanning of 131I rose bengal. In order to evaluate the possibility to differentiate these jaundices by 131I BSP fundamental evaluation of 131I BSP was performed. 131I BSP was specially prepared and supplied by Dinabot Radioisotope Laboratoy. Specifie activity is about 300 μCi/0.33 mg. Stability of the label during storage and in plasma was found to be satisfactory. Metabolism of 131I BSP in the rat, dog and man was studied and compared with 35S-BSP. 131I was accumulated into the liver of rat rapidly and excreted into intestine almost completely within 24 hours. 131I BSP has appeared in the bile in 30 min after injection. Chromatography of the 131I BSP in the bile revealed only single peak when compared with the formation of 3 & 4 band by 35S BSP. This indicate the the different metabolism (most possidly conjugation process) of 131I BSP. Clearance of tracer dose 131I BSP (0.66-2.0 mg/whole body) in man shows dissappearance rate constant of 0.099-0.193 (mean 0.193). This is remarkably slow when compared with the clearance of 35S BSP (0.222 for 0.1mg/kg, 0.162 for 1.0mg/kg and 0.136 for 2.5mg/kg). However, the clearance rate of 131I BSP is significantly high when compared with 131I rose bengal. Scintigram of 131I BSP in normal cases shows quick visualization of gall bladder & excretion into intestine. Scintigraphical evaluation of jaundiced cases is also to be published. |
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| Practice | Clinical medicine |
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