English
TitleThe Toxicologic Evaluation of Radio-Pharmaceuticals
Subtitle
AuthorsJONATHAN P.MILLER, L.E.MICHAEL CRAWFORD
Authors(kana)
OrganizationRadio-Pharmaceuticals Research Department, Abbott Laboratories
JournalThe Japanese Journal of nuclear medicine
Volume6
Number3
Page213-216
Year/Month1969/9
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractIn considering the potential toxicity of radio-pharmaceuticals, both chemical toxicity and radiation effects must be evaluated. Most modern radio-pharmaceuticals utilize "tracer" techniques and the mass administered is so minute that pharmacologic response is difficult to detect. Radio-Pharmaceutical agents are usually administered on a "single-dose" basis and they are not intended for chronic administration. Typical administered doses of various radio-pharmaceuticals are summarized in Table I. The small administered mass is directly related to the large safety factors established for radio-pharmaceuticals. Table II summarizes calculated factors based on typical doses to man and acute intravenous toxicity studies in mice. Because of physical decay of the radionuclide, the required injection volume must increase with time in order to administer a given amount of radioactivity. This decay factor can be significant with pharmacologically-active compounds labeled with short-lived nuclides; e.g., Chlormerodrin Hg 197.
PracticeClinical medicine
Keywords

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