| Japanese |
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| Title | カテーテル型半導体放射線検出器の製造と臨床医学への応用 |
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| Subtitle | 原著 |
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| Authors | 上田英雄*, 佐々木康人*, 開原成允*, 飯尾正宏*, 高柳誠一**, 小林哲二** |
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| Organization | *東京大学上田内科, **東芝中央研究所 |
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| Journal | 核医学 |
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| Volume | 3 |
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| Number | 2 |
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| Page | 110-120 |
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| Year/Month | 1966/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 放射性同位元素を生体に使用したさいの測定法としては, 体外からスタンド型の検出器を用いて測定するか, または生体からえた資料の一部, たとえば血液・尿・組織等を測定することが従来行なわれていた. しかし検出器を生体内に挿入して放射能を測定することができれば, 体外測定ではえられない新しい情報をうる可能性がある. この目的にneedle-typeのGM管が用いられある程度の成功を収めた. われわれもこの小型GM管を犬の心臓内に挿入し, 冠循環の循環時間を測定し, 本方法の有効であることを明らかにした. しかし本検出器はGM管の寿命が短いこと, 高電圧をかける必要のあること, 32Pのごとく高エネルギーのβ線にしか感受性のないこと等の欠点があり臨床的に応用しうるにはまだしもの感があった. 1951年Mckayによって半導体を用いて放射線を測定しうることが明らかにされ半導体放射線検出器の研究が始められた. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Clinical Application of Catheter-type Semiconductor Detector |
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| Authors | Hideo Ueda*, Yasuhito Sasaki*, Sigekoto Kaihara*, Masahiro Iio*, Seiichi Takayanagi**, Tetsuji Kobayashi** |
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| Organization | *東京大学上田内科, **東芝中央研究所 |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 3 |
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| Number | 2 |
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| Page | 110-120 |
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| Year/Month | 1966/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The development of catheter-type micro G-M counter made it possible to measure continuosly the instantaeous or integrated radioactivity of the tissue adjacent to the detector. Application of the detector for clinical medicine, however, was limited because of high operation voltage and its restricted sensitivity to high energy beta rays. Compared with this, semiconductor detector has such advantages as low operation voltage and sensitivity to wide range of beta radiations. We made this detector into catheter-type and investigated its usefulness in the field of nuclear medicine. The device used in our experiments is 7 mm in diameter and 15 mm. in length. The basic characteristics of the device were studied including noise level, reproducibility, effect of bias voltage and temperature on countrates, lineality of countrates to concentration of the radiation sources, sensitivity and isoresponse curve. Circulation time was measured in dogs from femoral vein to inferior vena cava and to tracha using krypton-85, with the detector inserted into the points of aim. Experiment with circulating models showed the possibility of continuous measurement of the blood flow using krypton-85 infusion. The possible uses of the catheter-type semiconductor detector in medicine were discussed. |
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| Practice | Clinical medicine |
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